Objective: To observe the clinical results and the changes of gingival crevicular fluid prostaglandins E(2) (GCF-PGE(2)) levels three months after indomethcin rinsing.
Methods: Nineteen periodontal patients who had received periodontal treatment before were chosen and divided into two groups randomly: indomethcin test group and placebo control group. The clinical parameters and gingival crevicular fluid (GCF) samples were obtained respectively at 0, 1, 3 month. The levels of GCF-PGE(2) were measured by radioimmunoassay (RIA).
Results: After 3 months' rinse treatment, the bleeding index and the amounts of GCF in test group decreased significantly than those of the control group. Attachment level improved in test group as well. The levels of GCF-PGE(2) significantly decreased in test group, which not changed in control group. The percentage value of plaque reduced considerably in both test group and control group after rinsing, but no significant difference was found between these two groups.
Conclusion: Gingival inflammation and the levels of GCF-PGE(2) are reduced after topical indomethcin administration. The effect is related to the decrease of local PGE(2) levels.