Friotherapy, using liquid N2 as cryogen, may be applied for all stages of liver cancer, which mechanism is tissue destruction due to low temperature, directly and improvement of immunity. At present, using multiprobe cryosurgical device result in many treatment options, such as procedure under open abdomen and staring blankly forward or percutaneously under Trus guidance. The advantages of cold therapy include its convenience, few complications, approval results, ect. With the invention of new probes and cryogen, cryosurgery as a treatment for liver cancer will have a good prospect.