Cytotoxic triterpenes from the twigs of Celtis philippinensis

Phytochemistry. 2003 Jan;62(2):197-201. doi: 10.1016/s0031-9422(02)00520-4.

Abstract

Two triterpene esters, 3beta-trans-sinapoyloxylup-20(29)-en-28-ol (1) and 3beta-trans-feruloyloxy-16 beta-hydroxylup-20(29)-ene (2), were isolated as cytotoxic constituents from the chloroform-soluble extract of the twigs of Celtis philippinensis, along with five known triterpenes, 3beta-O-(E)-feruloylbetulin (3), 3beta-O-(E)-coumaroylbetulin (4), betulin (5), 20-epibryonolic acid (6), and ursolic acid (7). The structures of 1 and 2 were assigned from their 1D and 2D NMR spectroscopic data. All isolates were evaluated for cytotoxicity against several human cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents, Phytogenic / analysis*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Death / drug effects*
  • Humans
  • Male
  • Molecular Structure
  • Plant Shoots / chemistry*
  • Triterpenes / analysis*
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*
  • Tumor Cells, Cultured
  • Ulmaceae / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Triterpenes