[Pharmacokinetic study of CPT-11, SN-38 and SN-38 glucuronide in the ascites, plasma and bile after intraperitoneal administration of CPT-11]

Shinsuke Natsui; Michio Maruyama; Takanori Ochiai; Kumi Hasegawa; Itaru Takashima; Takeshi Nagahama; Masakazu Ebuchi

[Pharmacokinetic study of CPT-11, SN-38 and SN-38 glucuronide in the ascites, plasma and bile after intraperitoneal administration of CPT-11]

Gan To Kagaku Ryoho. 2002 Nov;29(12):2188-90.

[Article in Japanese]

Authors

Shinsuke Natsui¹, Michio Maruyama, Takanori Ochiai, Kumi Hasegawa, Itaru Takashima, Takeshi Nagahama, Masakazu Ebuchi

Affiliation

¹ Dept. of Surgery, Tokyo Metropolitan Ohkubo Hospital.

PMID: 12484033

Abstract

We studied the pharmacokinetics of CPT-11 with intraperitoneal administration in a patient with a PTCD tube. The patient had advanced gastric cancer with peritoneal metastasis. CPT-11 was administrated in a dose of 40 mg and the intraperitoneal, plasma and bile levels of CPT-11, SN-38 and SN-38 glucuronide (SN-38 GLU) were measured periodically. The results showed that the periodical concentration pattern of CPT-11, SN-38 and SN-38 GLU in the bile was closely related to that of CPT-11 in the abdominal cavity.

Publication types

Case Reports

MeSH terms

Aged
Aged, 80 and over
Antineoplastic Agents, Phytogenic / administration & dosage*
Antineoplastic Agents, Phytogenic / pharmacokinetics*
Ascites / metabolism
Bile / chemistry
Camptothecin / administration & dosage*
Camptothecin / analogs & derivatives*
Camptothecin / pharmacokinetics*
Glucuronides / pharmacokinetics*
Humans
Infusions, Parenteral
Irinotecan
Male
Stomach Neoplasms / drug therapy

Substances

7-ethyl-10-hydroxycamptothecin glucuronide
Antineoplastic Agents, Phytogenic
Glucuronides
Irinotecan
Camptothecin