Exposure of human skin diploid fibroblasts to repeated subcytotoxic doses of ultraviolet-B induces the overexpression of transforming growth factor-beta1 mRNA

Ann N Y Acad Sci. 2002 Nov:973:44-8. doi: 10.1111/j.1749-6632.2002.tb04603.x.

Authors

Florence Chainiaux¹, Jose Remacle, Olivier Toussaint

Affiliation

¹ Laboratory of Cellular Biochemistry and Biology, Department of Biology, University of Namur (FUNDP), Namur, Belgium.

PMID: 12485831
DOI: 10.1111/j.1749-6632.2002.tb04603.x

Abstract

In this work we show that the steady state mRNA level of TGF-beta1 is significantly increased in UVB-induced premature senescence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Fibroblasts / immunology
Fibroblasts / pathology
Fibroblasts / radiation effects*
Humans
RNA, Messenger / genetics
RNA, Messenger / radiation effects
Reverse Transcriptase Polymerase Chain Reaction
Skin / radiation effects*
Transcription, Genetic*
Transforming Growth Factor beta / genetics*
Transforming Growth Factor beta1
Ultraviolet Rays*

Substances

RNA, Messenger
TGFB1 protein, human
Transforming Growth Factor beta
Transforming Growth Factor beta1