Extracellular ATP induces phosphatidylserine externalization earlier than nuclear apoptotic events in thymocytes

Marie-Pierre Courageot; Sandrine Lepine; Francoise Giraud; Jean-Claude Sulpice

doi:10.1111/j.1749-6632.2002.tb04630.x

Extracellular ATP induces phosphatidylserine externalization earlier than nuclear apoptotic events in thymocytes

Ann N Y Acad Sci. 2002 Nov:973:186-9. doi: 10.1111/j.1749-6632.2002.tb04630.x.

Authors

Marie-Pierre Courageot¹, Sandrine Lepine, Francoise Giraud, Jean-Claude Sulpice

Affiliation

¹ Biomembranes et Messagers Cellulaires, CNRS-UMR 8619, Université Paris XI, 91405 Orsay Cedex, France.

PMID: 12485858
DOI: 10.1111/j.1749-6632.2002.tb04630.x

Abstract

The present study shows for the first time that ATP(ec) induces a very early PS exposure in thymocytes and that this process can be induced in the absence of Ca(2+) influx and caspase activation.

MeSH terms

Adenosine Triphosphate / pharmacology*
Animals
Apoptosis / physiology*
Calcium / pharmacology
Cell Nucleus / physiology*
Cell Nucleus / ultrastructure
Cells, Cultured
Extracellular Space / physiology
Mice
Phosphatidylserines / metabolism*
T-Lymphocytes / cytology*
T-Lymphocytes / drug effects
T-Lymphocytes / physiology

Substances

Phosphatidylserines
Adenosine Triphosphate
Calcium