Abstract
It is generally accepted that ceramide plays an essential role in apoptosis. In this study we suggest that in thymocytes, dexamethasone-induced apoptosis is mediated by sphingosine rather than ceramide, through the activation of an aSMase and a cerase in a caspase-dependent manner.
MeSH terms
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Animals
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Cells, Cultured
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Ceramides / metabolism
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Dexamethasone / pharmacology*
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Kinetics
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Mice
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Sphingomyelin Phosphodiesterase / metabolism
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Sphingosine / metabolism*
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T-Lymphocytes / cytology
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T-Lymphocytes / drug effects*
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T-Lymphocytes / physiology*
Substances
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Ceramides
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Dexamethasone
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Sphingomyelin Phosphodiesterase
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Sphingosine