Abstract
We used Tellegen's Multidimensional Personality Questionnaire (MPQ) harm avoidance (fear) scale and the constraint superfactor as personality measures of inhibitory control and examined their association with glucose metabolism in the orbitofrontal gyrus at rest in 14 recently abstinent methamphetamine-dependent subjects and 22 comparison subjects. Higher MPQ scores were associated with higher relative orbitofrontal gyrus metabolism in the methamphetamine-dependent subjects. There was a tendency towards a negative association for the comparison subjects (test of coincidence of regression lines for the two subject groups: F = 3.3, df = 2,32; = 0.051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Age Factors
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Amphetamine-Related Disorders / diagnostic imaging
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Amphetamine-Related Disorders / metabolism*
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Amphetamine-Related Disorders / physiopathology
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Avoidance Learning / drug effects
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Avoidance Learning / physiology
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Brain Mapping
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Energy Metabolism / drug effects*
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Energy Metabolism / physiology
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Exploratory Behavior / drug effects
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Exploratory Behavior / physiology
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Fear / drug effects*
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Fear / physiology
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Fear / psychology
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Female
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Fluorodeoxyglucose F18
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Glucose / metabolism*
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Humans
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Male
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Methamphetamine / pharmacology*
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Middle Aged
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Neuropsychological Tests
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Prefrontal Cortex / diagnostic imaging
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Prefrontal Cortex / metabolism*
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Prefrontal Cortex / physiopathology
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Self-Injurious Behavior / diagnostic imaging
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Self-Injurious Behavior / metabolism
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Self-Injurious Behavior / physiopathology
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Sex Characteristics
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Tomography, Emission-Computed
Substances
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Fluorodeoxyglucose F18
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Methamphetamine
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Glucose