Low expression levels of p27 correlate with loco-regional recurrence in nasopharyngeal carcinoma

Chung-Feng Hwang; Chih-Ying Su; Shung-Chen Huang; Chao-Cheng Huang; Fu-Min Fang; Chun-Chung Lui; Hsueh-Wen Chang; Chung-Lung Cho

doi:10.1016/s0304-3835(02)00508-6

Low expression levels of p27 correlate with loco-regional recurrence in nasopharyngeal carcinoma

Cancer Lett. 2003 Jan 28;189(2):231-6. doi: 10.1016/s0304-3835(02)00508-6.

Authors

Chung-Feng Hwang¹, Chih-Ying Su, Shung-Chen Huang, Chao-Cheng Huang, Fu-Min Fang, Chun-Chung Lui, Hsueh-Wen Chang, Chung-Lung Cho

Affiliation

¹ Departments of Otolaryngology, Chang-Gung University, Chang-Gung Memorial Hospital, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan. [email protected]

PMID: 12490316
DOI: 10.1016/s0304-3835(02)00508-6

Abstract

To clarify the roles of p27 and c-myc in nasopharyngeal carcinoma (NPC), we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC. The results show that a low level of expression was observed in 47 and 41 cases, respectively. A low level of p27 expression was significantly correlated with loco-regional recurrence, and reduction in the c-myc protein was also correlated with neck metastasis in NPC. Our study indicates that a reduction in p27 expression is frequently seen in NPC. Furthermore, low expression levels of p27 and c-myc may contribute to the aggressive behavior of NPC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma / epidemiology
Carcinoma / genetics
Carcinoma / pathology*
Carcinoma / secondary
Cell Cycle Proteins / biosynthesis
Cell Cycle Proteins / genetics
Cell Cycle Proteins / physiology*
Cyclin-Dependent Kinase Inhibitor p27
Female
Gene Expression Regulation, Neoplastic*
Genes, myc
Head and Neck Neoplasms / secondary
Humans
Life Tables
Male
Middle Aged
Nasopharyngeal Neoplasms / epidemiology
Nasopharyngeal Neoplasms / genetics
Nasopharyngeal Neoplasms / pathology*
Neoplasm Invasiveness / genetics
Neoplasm Proteins / biosynthesis
Neoplasm Proteins / deficiency
Neoplasm Proteins / genetics
Neoplasm Proteins / physiology*
Neoplasm Recurrence, Local / epidemiology
Neoplasm Recurrence, Local / genetics
Neoplasm Recurrence, Local / pathology*
Proto-Oncogene Proteins c-myc / biosynthesis
Proto-Oncogene Proteins c-myc / deficiency
Proto-Oncogene Proteins c-myc / physiology*
Survival Analysis
Taiwan / epidemiology
Tumor Suppressor Proteins / biosynthesis
Tumor Suppressor Proteins / deficiency
Tumor Suppressor Proteins / genetics
Tumor Suppressor Proteins / physiology*

Substances

Cell Cycle Proteins
Neoplasm Proteins
Proto-Oncogene Proteins c-myc
Tumor Suppressor Proteins
Cyclin-Dependent Kinase Inhibitor p27