Abstract
Effects of bacterial pathogens on the production of macrophage inflammatory protein 3alpha (MIP-3alpha) and MIP-3beta from human peripheral blood neutrophils were investigated. Neutrophils produced both chemokines by coincubation with either gram-positive or gram-negative bacteria. Neutrophils may initiate antigen-specific immune responses through the release of these chemokines that are capable of promoting selective recruitment of dendritic cells and T-cell subsets.
MeSH terms
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Chemokine CCL20
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Chemokines, CC / biosynthesis*
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Chemokines, CC / metabolism
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Gram-Negative Bacteria / immunology*
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Gram-Positive Bacteria / immunology*
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Humans
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Macrophage Inflammatory Proteins / biosynthesis*
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Macrophage Inflammatory Proteins / metabolism
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Neutrophils / immunology
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Neutrophils / metabolism*
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Receptors, CCR6
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Receptors, Chemokine*
Substances
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CCL20 protein, human
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CCR6 protein, human
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Chemokine CCL20
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Chemokines, CC
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Macrophage Inflammatory Proteins
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Receptors, CCR6
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Receptors, Chemokine