[(123)I]-FP-CIT-SPECT in the early diagnosis of PD presenting as exercise-induced dystonia

Neurology. 2002 Dec 24;59(12):1974-6. doi: 10.1212/01.wnl.0000037484.28297.66.

Abstract

Isolated foot dystonia following exercise is a rare manifestation of early PD. It may precede the onset of parkinsonism by years and can be clinically indistinguishable from familial exercise-induced dystonia. The authors present a patient with dystonic claudication where dopamine transporter SPECT using (123)I-FP-CIT allowed early diagnosis of PD and enabled effective symptomatic treatment with a dopamine agonist.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dopamine Plasma Membrane Transport Proteins
  • Dystonia / etiology*
  • Electromyography
  • Exercise / physiology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Membrane Glycoproteins*
  • Membrane Transport Proteins / metabolism
  • Muscular Diseases / diagnostic imaging
  • Muscular Diseases / etiology
  • Nerve Tissue Proteins*
  • Neurologic Examination
  • Parkinson Disease / diagnostic imaging*
  • Radiopharmaceuticals
  • Tomography, Emission-Computed, Single-Photon
  • Tropanes

Substances

  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Radiopharmaceuticals
  • Tropanes
  • 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane