Aha, another regulator for hsp90 chaperones

Mol Cell. 2002 Dec;10(6):1255-6. doi: 10.1016/s1097-2765(02)00793-1.

Abstract

A large number of key regulators controlling homeostasis and cell fate are chaperoned by the Hsp90 folding machine. In this issue of Molecular Cell, report the discovery of a new stress-regulated cochaperone, Aha1, which accelerates the dynamics of this machine.

Publication types

  • Comment

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Dimerization
  • HSP90 Heat-Shock Proteins / genetics
  • HSP90 Heat-Shock Proteins / physiology*
  • Homeostasis
  • Humans
  • Molecular Chaperones / metabolism*
  • Protein Binding
  • Saccharomyces cerevisiae Proteins / metabolism*

Substances

  • HSP90 Heat-Shock Proteins
  • Molecular Chaperones
  • Saccharomyces cerevisiae Proteins
  • Adenosine Triphosphatases