Identification of t(15;17) and a segmental duplication of chromosome 11q23 in a patient with acute myeloblastic leukemia M2

Shibo Li; Lijun Zhang; William F Kern; Dario Andrade; Jean E Forsberg; Francesca R Bates; John J Mulvihill

doi:10.1016/s0165-4608(02)00588-5

Identification of t(15;17) and a segmental duplication of chromosome 11q23 in a patient with acute myeloblastic leukemia M2

Cancer Genet Cytogenet. 2002 Oct 15;138(2):149-52. doi: 10.1016/s0165-4608(02)00588-5.

Authors

Shibo Li¹, Lijun Zhang, William F Kern, Dario Andrade, Jean E Forsberg, Francesca R Bates, John J Mulvihill

Affiliation

¹ Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. [email protected]

PMID: 12505261
DOI: 10.1016/s0165-4608(02)00588-5

Abstract

A 32-year-old man was newly diagnosed with acute myelocytic leukemia, classified as acute myeloblastic leukemia with maturation (AML-M2) according to the French-American-British classification system. Conventional chromosome analysis before chemotherapy treatment revealed an abnormal karyotype: a possible segmental duplication of 11q23, plus a translocation between chromosomes 15 and 17 [t(15;17) (q22;q21.1)] in the majority of cells analyzed. Fluorescence in situ hybridization analysis using commercially available probes confirmed the cytogenetic findings. To our knowledge, this is the first report of a combination of t(15;17) and a segmental duplication of 11q23 in a patient with AML-M2.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bone Marrow / pathology
Chromosomes, Human, Pair 11 / genetics*
Chromosomes, Human, Pair 15 / genetics*
Chromosomes, Human, Pair 17 / genetics*
Gene Duplication*
Humans
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute / genetics*
Male
Translocation, Genetic / genetics*