Abstract
Human immunodeficiency virus (HIV) type 1 DNA assay data were obtained at baseline from 111 HIV-1-positive subjects who were treated with nucleosides. Higher baseline DNA level, HIV-1 RNA level, and infectious titer were comparably associated with an increased hazard of disease progression (each P<.03). Only DNA level was significantly associated with survival (adjusted hazard ratio for 1 log(10) higher level, 3.99; 95% confidence interval, 1.44-11.09; P=.008).
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / drug therapy*
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Acquired Immunodeficiency Syndrome / mortality
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Acquired Immunodeficiency Syndrome / virology
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Adult
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Anti-HIV Agents / therapeutic use*
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CD4 Lymphocyte Count
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DNA, Viral / analysis*
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Didanosine / administration & dosage
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Disease Progression
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HIV-1 / genetics*
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Humans
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Multivariate Analysis
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Prognosis
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RNA, Viral / blood
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Zalcitabine / administration & dosage
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Zidovudine / therapeutic use
Substances
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Anti-HIV Agents
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DNA, Viral
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RNA, Viral
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Zidovudine
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Zalcitabine
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Didanosine