Catalytic enantioselective epoxidation of homoallylic alcohols by chiral zirconium complexes

Org Lett. 2003 Jan 9;5(1):85-7. doi: 10.1021/ol027261t.

Abstract

Catalytic enantioselective epoxidation of homoallylic alcohols using Zr(Ot-Bu)(4) and tartrate ester (or tartramide) has been developed. In the Zr(Ot-Bu)(4)/diisopropyl tartrate-catalyzed epoxidation, the reverse of the enantiofacial preference was observed, depending on the Zr/ligand ratios of 1:1 or 1:2. [reaction--see text]