Abstract
Glucocorticoids have profound effects on mineral metabolism and skeletal cell function, and an excess can lead to the development of short stature and osteoporosis. The most significant actions of glucocorticoids are on chondrocytes and bone-forming cells, where they act, directly and indirectly, and regulate the local synthesis of insulin-like growth factor-I.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bone Remodeling / drug effects
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Bone and Bones / drug effects*
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Bone and Bones / metabolism
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CCAAT-Enhancer-Binding Protein-alpha / genetics
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Chondrocytes / drug effects
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Chondrocytes / physiology
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Glucocorticoids / pharmacology*
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Humans
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Insulin-Like Growth Factor I / biosynthesis
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Insulin-Like Growth Factor I / genetics
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Osteoblasts / drug effects
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Osteoblasts / physiology
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Osteoclasts / drug effects
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Osteoclasts / physiology
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Osteoporosis
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Promoter Regions, Genetic
Substances
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CCAAT-Enhancer-Binding Protein-alpha
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Glucocorticoids
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Insulin-Like Growth Factor I