Myocardial contrast echocardiography is a non-invasive method used to detect coronary artery disease. It was first described in 1968. New contrast agents which can go through the pulmonary vessels were discovered in the last years. Contrast echocardiography is useful in improving the endocardial border delineation and left ventricular cavity visualisation especially in patients with suboptimal acoustic windows. As the contrast passes further into the coronary artery normal myocardium perfusion is enhanced while ischaemic areas lack enhancement. Analysis of perfusion allows indirect identification of narrowed coronary arteries. Left ventricular function and its myocardium perfusion are made with contrast echocardiography at rest and during pharmacological stress tests. These examinations allow for detection patient with coronary artery disease as well as estimating efficacy of revascularisation procedures.