Abstract
To check the anti-apoptosis gene bcl-2 protein/mRNA expression in 28 acute promyelocytic leukemia (APL), by immunohistochemistry and in situ hybridization, and to analyse the relationship among the bcl-2 gene expressions, clinical prognosis and classification of the isoforms of fuse gene in APL. The result shows the two types of isoforms of PML-RAR alpha have no significance in bcl-2 protein/mRNA expression, indexes of clinical prognosis. This shows that the classification of PML-RAR alpha isoform has no influence on clinical prognosis.
MeSH terms
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Adolescent
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Adult
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Female
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Humans
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Leukemia, Promyelocytic, Acute / genetics*
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Male
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Middle Aged
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Neoplasm Proteins / genetics*
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Oncogene Proteins, Fusion / genetics*
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Prognosis
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Protein Isoforms / genetics
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Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
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Proto-Oncogene Proteins c-bcl-2 / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
Substances
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Neoplasm Proteins
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Oncogene Proteins, Fusion
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Protein Isoforms
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Proto-Oncogene Proteins c-bcl-2
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RNA, Messenger
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promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein