Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens

Hirotaka Shibuya; Chinami Kitamura; Shoji Maehara; Marie Nagahata; Hendig Winarno; Partomuan Simanjuntak; Hye-Sook Kim; Yusuke Wataya; Kazuyoshi Ohashi

doi:10.1248/cpb.51.71

Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens

Chem Pharm Bull (Tokyo). 2003 Jan;51(1):71-4. doi: 10.1248/cpb.51.71.

Authors

Hirotaka Shibuya¹, Chinami Kitamura, Shoji Maehara, Marie Nagahata, Hendig Winarno, Partomuan Simanjuntak, Hye-Sook Kim, Yusuke Wataya, Kazuyoshi Ohashi

Affiliation

¹ Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan. [email protected]

PMID: 12520132
DOI: 10.1248/cpb.51.71

Abstract

The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biotransformation
Cinchona / chemistry
Cinchona / microbiology*
Cinchona Alkaloids / chemistry*
Fungi* / chemistry
Fungi* / isolation & purification
Oxides / chemistry*
Plant Stems / chemistry
Plant Stems / microbiology

Substances

Cinchona Alkaloids
Oxides