Abstract
Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, CD / analysis
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Antigens, Differentiation, T-Lymphocyte / analysis
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CD3 Complex / analysis
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CD56 Antigen / analysis
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Hepatitis C / immunology*
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Humans
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Immunophenotyping
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Killer Cells, Natural / immunology*
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Lectins, C-Type
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Lymphocyte Activation
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Receptors, Antigen, T-Cell, alpha-beta / analysis*
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T-Lymphocyte Subsets / immunology*
Substances
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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CD3 Complex
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CD56 Antigen
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CD69 antigen
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Lectins, C-Type
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Receptors, Antigen, T-Cell, alpha-beta