Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection

J Virol. 2003 Feb;77(3):2251-7. doi: 10.1128/jvi.77.3.2251-2257.2003.

Abstract

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / analysis
  • Antigens, Differentiation, T-Lymphocyte / analysis
  • CD3 Complex / analysis
  • CD56 Antigen / analysis
  • Hepatitis C / immunology*
  • Humans
  • Immunophenotyping
  • Killer Cells, Natural / immunology*
  • Lectins, C-Type
  • Lymphocyte Activation
  • Receptors, Antigen, T-Cell, alpha-beta / analysis*
  • T-Lymphocyte Subsets / immunology*

Substances

  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • CD3 Complex
  • CD56 Antigen
  • CD69 antigen
  • Lectins, C-Type
  • Receptors, Antigen, T-Cell, alpha-beta