Anti-Ri antibody positive opsoclonus-myoclonus in a male patient with breast carcinoma

Paul W Wirtz; Peter A E Sillevis Smitt; Jorrit I Hoff; Bertie de Leeuw; Gert Jan Lammers; Sjoerd G van Duinen; Jan J Verschuuren

doi:10.1007/s00415-002-0913-z

Anti-Ri antibody positive opsoclonus-myoclonus in a male patient with breast carcinoma

J Neurol. 2002 Dec;249(12):1710-2. doi: 10.1007/s00415-002-0913-z.

Authors

Paul W Wirtz¹, Peter A E Sillevis Smitt, Jorrit I Hoff, Bertie de Leeuw, Gert Jan Lammers, Sjoerd G van Duinen, Jan J Verschuuren

Affiliation

¹ Department of Neurology, J3R-166, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands. [email protected]

PMID: 12529794
DOI: 10.1007/s00415-002-0913-z

Abstract

A 65-year-old male patient developed truncal ataxia, opsoclonus and myoclonus. In the serum anti-Ri antibodies were found, which led to the detection of a small adenocarcinoma of the breast. Other prominent clinical features were an excessive startle response and behavioral disorders, such as anxiety and impatience. These features suggest an immune response against both Nova-1 and Nova-2 antigens throughout the central nervous system.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Antibodies, Neoplasm / biosynthesis
Antibodies, Neoplasm / blood*
Antigens, Neoplasm / immunology*
Breast Neoplasms, Male / blood*
Breast Neoplasms, Male / diagnosis
Breast Neoplasms, Male / psychology
Humans
Male
Nerve Tissue Proteins*
Neuro-Oncological Ventral Antigen
Paraneoplastic Syndromes, Nervous System / blood*
Paraneoplastic Syndromes, Nervous System / diagnosis
Paraneoplastic Syndromes, Nervous System / psychology
RNA-Binding Proteins*

Substances

Antibodies, Neoplasm
Antigens, Neoplasm
Nerve Tissue Proteins
Neuro-Oncological Ventral Antigen
RNA-Binding Proteins