Ph-negative acute lymphocytic leukemia occurring after interferon therapy for Ph-positive chronic myelocytic leukemia

Leuk Res. 2003 Apr;27(4):367-9. doi: 10.1016/s0145-2126(02)00175-3.

Abstract

We report a unique case of chronic myelocytic leukemia (CML) with the Philadelphia (Ph) chromosome. The patient obtained cytogenetic complete remission (CR) after treatment with interferon (IFN). When he transformed to acute lymphocytic leukemia (ALL), cytogenetic analysis showed that the karyotype was normal and fluorescence in situ hybridization (FISH) indicated that blast cells were Ph-negative. Immunophenotyping showed that the cells were CD34-positive and CD38-negative. Blast cells in his final stage were BCR/ABL rearrangement negative by reverse transcription polymerase chain reaction (RT-PCR).

Publication types

  • Case Reports

MeSH terms

  • Cell Transformation, Neoplastic / pathology
  • Clone Cells / pathology
  • Cytogenetic Analysis
  • Fatal Outcome
  • Humans
  • Immunophenotyping
  • Interferon-alpha / administration & dosage*
  • Interferon-alpha / adverse effects
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / chemically induced*
  • Neoplasms, Second Primary / genetics*
  • Neoplasms, Second Primary / pathology
  • Philadelphia Chromosome*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / chemically induced*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology

Substances

  • Interferon-alpha