Chronic lymphocytic leukaemia developing in the course of chronic myeloid leukaemia

Leuk Lymphoma. 2002 Nov;43(11):2225-7. doi: 10.1080/1042819021000016140a.

Abstract

Both chronic myeloid leukaemia (CML) and chronic lymphocytic leukaemia (CLL) are rare illnesses. Their co-existence has been previously reported, typically with CML following CLL. We report to our knowledge the first case of CLL developing some years after initial diagnosis of Philadelphia (Ph) chromosome positive CML. We provide molecular evidence that CLL arose in a Ph negative clone. The implications of the findings are discussed.

Publication types

  • Case Reports

MeSH terms

  • Benzamides
  • Clone Cells / pathology
  • Disease Progression
  • Female
  • Gene Rearrangement
  • Humans
  • Imatinib Mesylate
  • Immunoglobulin Heavy Chains / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / drug therapy
  • Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / pathology
  • Middle Aged
  • Neoplasms, Second Primary / pathology
  • Philadelphia Chromosome
  • Piperazines / therapeutic use
  • Pyrimidines / therapeutic use

Substances

  • Benzamides
  • Immunoglobulin Heavy Chains
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate