Abstract
Fostriecin, a potent protein phosphatase inhibitor and antitumor agent, has been enantioselectively synthesized in naturally occurring form via a versatile route, which also allows one to secure all possible stereoisomeres of the C1-C13 fragment including the C11 stereocenter and the geometry of the delta 12-double bond.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / chemistry
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Alkenes / isolation & purification
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Antibiotics, Antineoplastic / chemical synthesis*
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification
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Chromatography, High Pressure Liquid
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Phosphoprotein Phosphatases / antagonists & inhibitors
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Polyenes
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Pyrones
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Stereoisomerism
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Streptomyces / metabolism
Substances
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Alkenes
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Antibiotics, Antineoplastic
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Enzyme Inhibitors
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Polyenes
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Pyrones
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Phosphoprotein Phosphatases
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fostriecin