An integrated computational pipeline and database to support whole-genome sequence annotation

Genome Biol. 2002;3(12):RESEARCH0081. doi: 10.1186/gb-2002-3-12-research0081. Epub 2002 Dec 23.

Abstract

We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Computational Biology / methods*
  • Databases, Genetic*
  • Genome*
  • Humans
  • Internet
  • Software Design*