[Separation and determination of pseudoephedrine in bufferin cold tablet by capillary electrophoresis with hydropropyl-beta-cyclodextrin as chiral selective reagent]

X F Wu; Y F Chai; L L Liu; Z Y Lou; J W Li; G Q Zhang; B Wang

[Separation and determination of pseudoephedrine in bufferin cold tablet by capillary electrophoresis with hydropropyl-beta-cyclodextrin as chiral selective reagent]

Se Pu. 2001 Nov;19(6):552-4.

[Article in Chinese]

Authors

X F Wu¹, Y F Chai, L L Liu, Z Y Lou, J W Li, G Q Zhang, B Wang

Affiliation

¹ College of Pharmaceutical Science, Second Military Medical University, Shanghai 200433, China.

PMID: 12545473

Abstract

A method for the separation and analysis of the chiral pseudoephedrine enantiomers using capillary electrophoresis was established. The buffer solution for separation was 25 mmol/L Tris-phosphate, including 38 mmol/L hydropropyl-beta-cyclodextrin with pH value of 2.65. (1S, 2S)(+) Pseudoephedrine in Bufferin Cold tablet was determined. The method has good precision, recovery and linear relationship.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2-Hydroxypropyl-beta-cyclodextrin
Cyclodextrins*
Drug Combinations
Electrophoresis, Capillary / instrumentation*
Electrophoresis, Capillary / methods
Ephedrine / isolation & purification*
Stereoisomerism
Tablets
Vasoconstrictor Agents / isolation & purification
beta-Cyclodextrins*

Substances

Cyclodextrins
Drug Combinations
Tablets
Vasoconstrictor Agents
beta-Cyclodextrins
2-Hydroxypropyl-beta-cyclodextrin
Ephedrine