Simultaneous radiochemotherapy in pediatric patients with high-grade glioma: a phase I study

Anticancer Res. 2002 Nov-Dec;22(6B):3569-72.

Abstract

Background: Sandwich chemotherapy as first postoperative treatment might cause resistance to ensuing irradiation. Simultaneous radiochemotherapy might prevent this.

Patients and methods: Twenty-nine children with high-grade glioma were treated from 1997-1999. The median age was 11.1 years. Tumor locations included: cerebral cortex 12, deep cerebral locations 11, cerebellum 3, spinal cord 3. Pons was excluded. Total (n = 9), subtotal (n = 3) and partial (n = 9) tumor resection or biopsy (n = 7) were followed by radiochemotherapy: fractionated radiation (1.8 Gyld up to 59.4 Gy) was given simultaneously with two cycles of chemotherapy (cisplatin 20 mg/m2/d x 5d, etoposide 100 mg/m2/d x 3d, and cisplatin, etoposide, ifosfamide: 1.5 g/m2/d). The data of a previous protocol (Cancer 89: 2131-7, 2000) in the same population were used as controls.

Results: Early progressive disease (PD 2 out of 25 patients) was significantly less frequent as compared to the control group (p = 0.031). The toxicity appeared tolerable.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Astrocytoma / drug therapy
  • Astrocytoma / radiotherapy
  • Astrocytoma / surgery
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / radiotherapy*
  • Brain Neoplasms / surgery
  • Child
  • Child, Preschool
  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects
  • Cohort Studies
  • Combined Modality Therapy / adverse effects
  • Dose Fractionation, Radiation
  • Etoposide / administration & dosage
  • Etoposide / adverse effects
  • Female
  • Glioblastoma / drug therapy
  • Glioblastoma / radiotherapy
  • Glioblastoma / surgery
  • Glioma / drug therapy*
  • Glioma / radiotherapy*
  • Glioma / surgery
  • Humans
  • Ifosfamide / administration & dosage
  • Ifosfamide / adverse effects
  • Male
  • Prospective Studies
  • Spinal Cord Neoplasms / drug therapy*
  • Spinal Cord Neoplasms / radiotherapy*
  • Spinal Cord Neoplasms / surgery

Substances

  • Etoposide
  • Cisplatin
  • Ifosfamide