Abstract
p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in senescent cultures or metastatic tumor-derived cell lines. The selective presence of p63 in basal cells of the prostate suggests that p63 can be used as a marker of basal cells and in vitro typing cell cultures of prostate cancer (CaP). The basal cell association underscores its critical functions in the biology of basal cells.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Aged
-
Biomarkers, Tumor / biosynthesis
-
Biomarkers, Tumor / genetics
-
DNA-Binding Proteins
-
Epithelial Cells / metabolism
-
Epithelial Cells / physiology
-
Genes, Tumor Suppressor
-
Humans
-
Immunohistochemistry
-
Male
-
Membrane Proteins*
-
Middle Aged
-
Neoplasm Staging
-
Phosphoproteins / biosynthesis*
-
Phosphoproteins / genetics
-
Prostatic Neoplasms / genetics
-
Prostatic Neoplasms / metabolism*
-
Prostatic Neoplasms / pathology
-
Reverse Transcriptase Polymerase Chain Reaction
-
Trans-Activators / biosynthesis*
-
Trans-Activators / genetics
-
Transcription Factors
-
Tumor Cells, Cultured
-
Tumor Suppressor Proteins
Substances
-
Biomarkers, Tumor
-
CKAP4 protein, human
-
DNA-Binding Proteins
-
Membrane Proteins
-
Phosphoproteins
-
TP63 protein, human
-
Trans-Activators
-
Transcription Factors
-
Tumor Suppressor Proteins