[Two cases of complete response to combination chemotherapy of gemcitabine and docetaxel for recurrent ovarian cancer]

Gan To Kagaku Ryoho. 2003 Jan;30(1):141-4.
[Article in Japanese]

Abstract

The established standard treatment for advanced ovarian cancer is carboplatin and paclitaxel. However, more than 70% of patients have recurrent disease. The standard therapy for recurrent ovarian cancer has not been confirmed. It was reported that docetaxel had a 30-40% of response rate in patients with recurrent ovarian cancer, and that gemcitabine had a 13-22% response rate. The combination chemotherapy of gemcitabine and docetaxel is also applied to non-small cell lung cancer. We use a regimen of 800 mg/m2 of gemcitabine on day 1 and day 8 in combination with 70 mg/m2 of docetaxel on day 8 with a 3-week interval. We treated 2 patients with recurrent ovarian cancer who responded completely to combination chemotherapy with gemcitabine and docetaxel.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carcinoma, Endometrioid / drug therapy*
  • Carcinoma, Endometrioid / secondary
  • Cystadenocarcinoma, Serous / drug therapy*
  • Cystadenocarcinoma, Serous / secondary
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / analogs & derivatives*
  • Docetaxel
  • Drug Administration Schedule
  • Female
  • Gemcitabine
  • Humans
  • Middle Aged
  • Ovarian Neoplasms / drug therapy*
  • Paclitaxel / administration & dosage
  • Paclitaxel / analogs & derivatives*
  • Pelvic Neoplasms / secondary*
  • Taxoids*

Substances

  • Taxoids
  • Deoxycytidine
  • Docetaxel
  • Paclitaxel
  • Gemcitabine