A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network

Am J Hypertens. 2003 Feb;16(2):148-50. doi: 10.1016/s0895-7061(02)03247-8.

Abstract

Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Black People* / genetics*
  • Black or African American
  • Chromosome Mapping
  • Chromosomes, Human, Pair 2 / genetics
  • Databases as Topic
  • Genetic Linkage*
  • Genetic Predisposition to Disease / genetics
  • Genome, Human*
  • Government Programs
  • Humans
  • Hypertension / ethnology*
  • Hypertension / genetics*
  • Lod Score
  • National Institutes of Health (U.S.)
  • Siblings*
  • Telomere
  • United States
  • White People / genetics*