Hepatitis C virus-related mixed cryoglobulinemia is a vasculitis, associated with a number of systemic manifestations and diseases. The Authors present a patient with mixed cryoglobulinemia, who developed acute abdominal pain and severe anemia, caused by spontaneous haematoma of rectus abdominis sheath. Prompt diagnosis of this unusual complication of cryoglobulinemia vasculitis may allow conservative treatment and avoid surgery, which is more expensive and invasive. To the best of Author's knowledge, spontaneous rectus sheath haematoma in a patient with cryoglobulinemia has not been previously reported.