Abstract
Following the discovery of the aquaporin-1 water channel in 1991, molecular techniques have been developed to examine the roles of renal aquaporins-1, -2, -3, and -4 in disorders of water balance. This article reviews current knowledge regarding aquaporin function and dysfunction in water-losing and water-retaining states.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Aquaporin 1
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Aquaporin 2
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Aquaporin 3
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Aquaporin 4
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Aquaporin 6
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Aquaporins / physiology*
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Blood Group Antigens
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Diabetes Insipidus / pathology
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Humans
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Kidney / metabolism*
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Kidney / physiology
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Models, Biological
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Models, Molecular
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Water / metabolism
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Water-Electrolyte Imbalance / pathology
Substances
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AQP1 protein, human
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AQP2 protein, human
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AQP3 protein, human
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AQP4 protein, human
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Aquaporin 2
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Aquaporin 4
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Aquaporin 6
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Aquaporins
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Blood Group Antigens
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Water
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Aquaporin 1
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Aquaporin 3