Abstract
A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed.
MeSH terms
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Animals
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Blood Glucose / metabolism
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / drug therapy
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Drug Design
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Hypoglycemic Agents / chemical synthesis*
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Hypoglycemic Agents / pharmacology
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Hypolipidemic Agents / chemical synthesis*
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Hypolipidemic Agents / pharmacology
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Mice
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Oxazines / chemical synthesis*
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Oxazines / pharmacology*
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Propionates / chemical synthesis*
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Receptors, Cytoplasmic and Nuclear / drug effects
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Spectrophotometry, Infrared
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Structure-Activity Relationship
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Transcription Factors / drug effects
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Triglycerides / blood
Substances
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Blood Glucose
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Hypoglycemic Agents
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Hypolipidemic Agents
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Indicators and Reagents
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Oxazines
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Propionates
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors
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Triglycerides