Evidence of cardiac ischemia during seizures in drug refractory epilepsy patients

Neurology. 2003 Feb 11;60(3):492-5. doi: 10.1212/01.wnl.0000042090.13247.48.

Abstract

The authors investigated whether patients with drug refractory epilepsy have cardiovascular abnormalities that might be related to a high frequency of sudden death. Twenty-three subjects underwent comprehensive cardiovascular evaluations before and during video-EEG monitoring. ST-segment depression occurred in 40% and was associated with a higher maximum heart rate during seizures. These data suggest that cardiac ischemia may occur in these patients.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Cohort Studies
  • Drug Resistance
  • Electrocardiography*
  • Electroencephalography
  • Epilepsies, Partial / complications
  • Epilepsies, Partial / drug therapy
  • Epilepsies, Partial / physiopathology*
  • Female
  • Heart Block / diagnosis
  • Heart Block / therapy
  • Heart Rate
  • Humans
  • Male
  • Middle Aged
  • Monitoring, Physiologic
  • Myocardial Ischemia / complications
  • Myocardial Ischemia / diagnosis*
  • Prospective Studies
  • Risk
  • Seizures / complications
  • Seizures / drug therapy
  • Seizures / physiopathology*
  • Video Recording