Coagulopathy and outcome in patients with chronic subdural haematoma

Acta Neurol Scand. 2003 Feb;107(2):110-6. doi: 10.1034/j.1600-0404.2003.01340.x.

Abstract

Objective: The coincidence of coagulatopathy and chronic subdural haematoma (CSH) requires correction of coagulation to facilitate surgery. We investigated the correlation between coagulopathy and outcome in CSH patients.

Material and methods: We analysed past medical history, surgical treatment and coagulation parameters of 114 patients.

Results: Coagulation disorders were found in 42%. Preoperative treatment with prothrombin complex concentrate was necessary in 14%. A significant difference (P < 0.05) of the preoperative level of platelets was found between recurrent CSH and non-recurrent group. Totally, we had to perform re-operations in 17.5%. Eighty-one patients presented with Glasgow coma scale (GCS) > or = 13. After surgery GCS was > or = 13 in n = 92. There was an improvement of GCS in 46 cases, 61 patients maintained GCS score levels. Outcome was significantly worse in the alcoholic group (P < 0.001), and in the recurrent group (P < 0.05). In patients with substitution of coagulation factors, outcome was worse in the group with post-operative substitution only (P < 0.05).

Conclusion: In CSH, the coagulation parameters and a subtle correction of coagulation are of special interest, regarding the worse outcome in patients with recurrent CSH and in those requiring post-operative substitution.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Alcoholism / complications
  • Anticoagulants / adverse effects
  • Blood Coagulation Disorders / complications
  • Blood Coagulation Disorders / diagnosis*
  • Blood Coagulation Disorders / drug therapy
  • Blood Coagulation Factors / administration & dosage
  • Blood Coagulation Tests
  • Chronic Disease
  • Craniotomy
  • Factor XIII Deficiency / complications
  • Factor XIII Deficiency / diagnosis
  • Factor XIII Deficiency / drug therapy
  • Female
  • Glasgow Coma Scale
  • Hematoma, Subdural / complications
  • Hematoma, Subdural / diagnosis*
  • Hematoma, Subdural / pathology
  • Hematoma, Subdural / surgery*
  • Humans
  • Male
  • Middle Aged
  • Phenprocoumon / adverse effects
  • Platelet Count
  • Postoperative Hemorrhage / etiology
  • Postoperative Hemorrhage / prevention & control
  • Preoperative Care
  • Recurrence
  • Reoperation
  • Survival Rate
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Anticoagulants
  • Blood Coagulation Factors
  • prothrombin complex concentrates
  • Phenprocoumon