Circadian clocks: a tale of two feedback loops

Cell. 2003 Feb 7;112(3):284-6. doi: 10.1016/s0092-8674(03)00076-x.

Abstract

Circadian clocks in a wide range of organisms are thought to consist of two interdependent transcriptional feedback loops. In Drosophila, the first loop has been well characterized and controls rhythmic period expression. In this issue of Cell, define a role for a transcriptional activator and a repressor in the second feedback loop.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Clocks / genetics*
  • CLOCK Proteins
  • Circadian Rhythm / genetics*
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / metabolism
  • Feedback / physiology*
  • Gene Expression Regulation / genetics
  • Models, Biological
  • Transcription Factors / genetics
  • Transcriptional Activation / genetics

Substances

  • Clk protein, Drosophila
  • Drosophila Proteins
  • Transcription Factors
  • CLOCK Proteins