Abstract
Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Adhesion Molecules / genetics
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Cell Adhesion Molecules / metabolism
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Cells, Cultured
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HeLa Cells
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Herpesvirus 1, Human / pathogenicity*
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Humans
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Mice
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Nectins
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Neurons, Afferent / virology*
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Rats
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Receptors, Tumor Necrosis Factor / genetics
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Receptors, Tumor Necrosis Factor / metabolism
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Receptors, Tumor Necrosis Factor, Member 14
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Receptors, Virus / genetics
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Receptors, Virus / metabolism
Substances
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Cell Adhesion Molecules
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NECTIN1 protein, human
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Nectin1 protein, mouse
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Nectins
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Member 14
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Receptors, Virus
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TNFRSF14 protein, human
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Tnfrsf14 protein, mouse