Abstract
An efficient synthesis of N,N'-substituted guanidine derivatives was developed via an aromatic sulfonyl-activated thiourea intermediate. The use of certain aromatic sulfonamides, such as PbfNH(2), as the key reagent to incorporate a TFA-labile guanidine protection group greatly facilitates solid-phase synthesis of N,N'-substituted guanidine compounds.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Catalysis
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Combinatorial Chemistry Techniques
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Guanidines / chemical synthesis*
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Indicators and Reagents
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Molecular Structure
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Sulfonamides / chemistry
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Thiourea / chemistry*
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Trifluoroacetic Acid / chemistry*
Substances
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Guanidines
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Indicators and Reagents
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Sulfonamides
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Trifluoroacetic Acid
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Thiourea