[Synthesis and binding affinity of 3-aryl-7-hydroxycoumarins to human alpha and beta estrogen receptors]

S Kirkiacharian; A T Lormier; M Resche-Rigon; F Bouchoux; E Cérède

[Synthesis and binding affinity of 3-aryl-7-hydroxycoumarins to human alpha and beta estrogen receptors]

Ann Pharm Fr. 2003 Jan;61(1):51-6.

[Article in French]

Authors

S Kirkiacharian¹, A T Lormier, M Resche-Rigon, F Bouchoux, E Cérède

Affiliation

¹ Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud, 5 rue Jean-Baptiste Clément, F92296-Chatenay Malabry Cedex.

PMID: 12589254

Abstract

The synthesis of a set of substituted 3-aryl-7-hydroxycoumarins was performed. The study of the relations between their structure and their relative binding affinity (RBA) to human alpha and B estrogen receptors was achieved.

Publication types

English Abstract

MeSH terms

Cells, Cultured
Coumarins / chemical synthesis*
Coumarins / metabolism
Estrogen Receptor alpha
Estrogen Receptor beta
Humans
Indicators and Reagents
Receptors, Estrogen / metabolism*

Substances

Coumarins
Estrogen Receptor alpha
Estrogen Receptor beta
Indicators and Reagents
Receptors, Estrogen