[A quantitative analysis of peptidergic innervation in sinoatrial node in cases of sudden manhood death syndrome]

Fa Yi Xue Za Zhi. 2002 May;18(2):70, 73.
[Article in Chinese]

Abstract

Objective: To study the distribution and proportion of neuropeptide containing nervers in the sinus node in cases of sudden manhood death syndrome (SMDS) and to explore the mechanism of SMDS.

Methods: Immunohistochemical staining and quantitative analysis of neuropeptide Y (NPY) and vasoactive intestinal peptide(VIP) in the sinus node in 6 cases of SMDS and in 12 cases of non-cardiac death(control group) were achieved by LSAB method and computerized image system.

Results: As for NPY positive materials, VIP positive materials and the ratio of VIP/NPY in the sinus nodes, there were no significant difference between the control group and SMDS group.

Conclusion: The mechanism of SMDS and the abnormality of autonomic nervous innervation in the sinoatrial nodes maybe incorrelation.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autonomic Nervous System / physiology
  • Death, Sudden / etiology
  • Death, Sudden / pathology*
  • Humans
  • Immunohistochemistry
  • Male
  • Myocardium / metabolism*
  • Neuropeptide Y / metabolism*
  • Sinoatrial Node / innervation*
  • Vasoactive Intestinal Peptide / metabolism*

Substances

  • Neuropeptide Y
  • Vasoactive Intestinal Peptide