Abstract
The rates of resistance to erythromycin and clindamycin among Streptococcus agalactiae strains isolated in our hospital increased from 4.2 and 0.8% in 1993 to 17.4 and 12.1%, respectively, in 2001. Erythromycin resistance was mainly due to the presence of an Erm(B) methylase, while the M phenotype was detected in 3.8% of the strains. Telithromycin was very active against erythromycin-resistant strains, irrespective of their mechanisms of macrolide resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Clindamycin / pharmacology*
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Cross Infection / epidemiology
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Cross Infection / microbiology
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Cross Infection / prevention & control
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Drug Resistance, Bacterial
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Erythromycin / pharmacology*
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Humans
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Infant, Newborn
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Ketolides*
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Macrolides*
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Microbial Sensitivity Tests
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Spain / epidemiology
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Streptococcal Infections / epidemiology
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Streptococcal Infections / microbiology
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Streptococcal Infections / prevention & control
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Streptococcus agalactiae / drug effects*
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Tetracycline Resistance
Substances
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Anti-Bacterial Agents
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Ketolides
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Macrolides
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Clindamycin
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Erythromycin
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telithromycin