Abstract
Two multidrug-resistant Salmonella enterica serovar Wien strains (SW468 and SW1107) were isolated in 2001 in Tunis. Both strains produced the beta-lactamases TEM-1, SHV-2a, and CMY-4, whereas strain SW1107 also produced the beta-lactamase CTX-M-3. The imipenem-resistant strain (SW468) was totally devoid of the OmpF-immunorelated porin. Imipenem resistance was shown as being related to porin loss and CMY-4 beta-lactamase production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Quinolones
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / pharmacology
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Bacterial Outer Membrane Proteins / biosynthesis
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Bacterial Outer Membrane Proteins / chemistry
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DNA Primers
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Drug Resistance, Bacterial
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Humans
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Imipenem / pharmacology*
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Infant, Newborn
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Plasmids / genetics
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Porins / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
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Salmonella enterica / drug effects*
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Salmonella enterica / genetics
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Thienamycins / pharmacology*
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Transformation, Bacterial
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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4-Quinolones
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Anti-Bacterial Agents
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Anti-Infective Agents
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Bacterial Outer Membrane Proteins
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DNA Primers
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OmpF protein
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Porins
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Thienamycins
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Imipenem
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beta-Lactamases
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beta-lactamase CMY-4, Salmonella enterica