Abstract
Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I-like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Aging*
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Animals
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Biological Evolution
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / physiology
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Caloric Restriction
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Drosophila / genetics
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Drosophila / physiology
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Dwarfism / physiopathology
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Gene Expression Regulation
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Glucose / metabolism*
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Growth Hormone / metabolism
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Human Growth Hormone / metabolism
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Humans
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Insulin-Like Growth Factor I / metabolism*
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Longevity* / genetics
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Mice
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Models, Animal
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Mutation
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Signal Transduction
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Yeasts / genetics
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Yeasts / physiology
Substances
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Human Growth Hormone
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Insulin-Like Growth Factor I
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Growth Hormone
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Glucose