Abstract
Neutrophils of patients with chronic granulomatous disease (CGD) are profoundly defective in killing microorganisms. As in patients with chemotherapy-induced neutropenia, CGD patients are highly susceptible to life-threatening invasive Aspergillus infections, and conventional antimycotic treatment is not always successful. The new drug, caspofungin, was used to treat Aspergillus lung infection in one child with CGD.
MeSH terms
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Adolescent
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Anti-Bacterial Agents / administration & dosage*
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Aspergillosis / diagnosis
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Aspergillosis / drug therapy*
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Aspergillus fumigatus / drug effects*
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Aspergillus fumigatus / isolation & purification
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Caspofungin
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Echinocandins
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Follow-Up Studies
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Granulomatous Disease, Chronic / diagnosis*
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Humans
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Lipopeptides
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Lung Diseases, Fungal / diagnosis
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Lung Diseases, Fungal / drug therapy*
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Male
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Opportunistic Infections / diagnosis
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Opportunistic Infections / drug therapy*
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Peptides*
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Peptides, Cyclic*
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Echinocandins
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Lipopeptides
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Peptides
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Peptides, Cyclic
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Caspofungin