Design and synthesis of potent N1-substituted indole melatonin receptor agonists

Chem Commun (Camb). 2003 Feb 7:(3):382-3.

Abstract

The design and expeditious synthesis of two new indole analogs with up to 5-fold potency of that of melatonin is described.

MeSH terms

  • Animals
  • Drug Design
  • Indoles / chemical synthesis*
  • Indoles / pharmacology
  • Ligands
  • Melatonin / analogs & derivatives*
  • Melatonin / chemical synthesis
  • Receptors, Cell Surface / agonists*
  • Receptors, Cytoplasmic and Nuclear / agonists*
  • Receptors, Melatonin
  • Structure-Activity Relationship
  • Xenopus laevis / metabolism

Substances

  • Indoles
  • Ligands
  • Receptors, Cell Surface
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Melatonin
  • Melatonin