Hydroporphyrins as tumour photosensitizers: synthesis and photophysical studies of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin

Bioorg Med Chem Lett. 2003 Mar 10;13(5):833-5. doi: 10.1016/s0960-894x(03)00002-7.

Abstract

The synthesis and characterization of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin is reported. The phototoxicity on C6 cell lines and the pharmacokinetics are also reported as preliminary results showing a very high tumor to skin ratio and short retention time in tissues, and thus promising activity in photodynamic therapy.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Mesoporphyrins / pharmacokinetics
  • Mesoporphyrins / pharmacology
  • Mice
  • Neoplasms, Experimental
  • Photochemotherapy / methods
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / pharmacokinetics
  • Photosensitizing Agents / pharmacology*
  • Porphyrins / chemistry*
  • Porphyrins / pharmacokinetics
  • Porphyrins / pharmacology*
  • Rats
  • Reference Standards
  • Skin Neoplasms / drug therapy
  • Spectrometry, Fluorescence
  • Tissue Distribution
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Mesoporphyrins
  • Photosensitizing Agents
  • Porphyrins
  • temoporfin