Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in Brazil

Am J Primatol. 2003 Mar;59(3):123-8. doi: 10.1002/ajp.10069.

Abstract

The rhesus macaque breeding colony of the Oswaldo Cruz Foundation (FIOCRUZ) was established in 1932 from a founding stock of 100 animals. This population has remained closed to new animal introductions for almost 70 years. A serologic survey was performed to determine the prevalence of antibodies to selected viruses as a first approach to identifying viral pathogens endemic in this population. Banked serum samples were tested for antibodies to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV), simian type D retrovirus (SRV), cercopithecine herpesvirus type-1 (B virus), rhesus cytomegalovirus (RhCMV), measles virus (MV), and hepatitis A virus (HAV). All samples were negative for antibodies against the simian retroviruses. The overall prevalence of antibodies was 95% for RhCMV, 45% for B virus, 35% for HAV, and 1% for MV. Prevalence was found to vary by age group.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Viral / blood*
  • Betaretrovirus / isolation & purification
  • Brazil / epidemiology
  • Cytomegalovirus / isolation & purification
  • Female
  • Hepatitis A virus / isolation & purification
  • Herpesvirus 1, Cercopithecine / isolation & purification
  • Macaca fascicularis / virology*
  • Macaca mulatta / immunology*
  • Macaca mulatta / virology*
  • Male
  • Measles virus / isolation & purification
  • Monkey Diseases / epidemiology
  • Monkey Diseases / immunology
  • Monkey Diseases / virology*
  • Seroepidemiologic Studies
  • Simian Immunodeficiency Virus / isolation & purification
  • Simian T-lymphotropic virus 1 / isolation & purification

Substances

  • Antibodies, Viral