Spontaneous hemarthrosis of the knee associated with clopidogrel and aspirin treatment

Z Rheumatol. 2003 Feb;62(1):80-1. doi: 10.1007/s00393-003-0420-3.

Abstract

We report a case of a 76-year-old-man who developed spontaneous hemarthrosis of his right knee following clopidogrel-aspirin treatment. Clopidogrel is an ADP receptor antagonist and in combination with aspirin widely used in patients with atherosclerotic vascular disease to reduce the incidence of ischemic events. To date, no case of spontaneous hemarthrosis following clopidogrel-aspirin therapy has been reported. Prompt aspiration after discontinuing the ADP receptor antagonist-aspirin combination therapy can assist early diagnosis and may prevent further damage to the joint. In conclusion, spontaneous hemarthrosis is a possible complication following clopidogrel-aspirin therapy and is recommended to be evaluated when appropriate clinical symptoms (e.g., intraarticular effusion) present.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angina, Unstable / drug therapy*
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Aspirin / administration & dosage
  • Aspirin / adverse effects*
  • Blood Coagulation Tests
  • Clopidogrel
  • Drug Interactions
  • Drug Therapy, Combination
  • Hemarthrosis / chemically induced*
  • Hemarthrosis / diagnosis
  • Humans
  • Male
  • Myocardial Infarction / drug therapy*
  • Osteoarthritis, Knee / diagnosis
  • Platelet Aggregation Inhibitors / adverse effects*
  • Platelet Aggregation Inhibitors / therapeutic use
  • Purinergic P2 Receptor Antagonists*
  • Risk Factors
  • Ticlopidine / administration & dosage
  • Ticlopidine / adverse effects*
  • Ticlopidine / analogs & derivatives

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Platelet Aggregation Inhibitors
  • Purinergic P2 Receptor Antagonists
  • Clopidogrel
  • Ticlopidine
  • Aspirin