Varicella vaccination during early pregnancy: a cause of in utero miliary fetal tissue calcifications and hydrops?

Infect Dis Obstet Gynecol. 2002;10(3):159-60. doi: 10.1155/S1064744902000169.

Abstract

Background: It is the purpose of this article to describe a suspected association of inadvertent vaccination with varicella vaccine during early pregnancy with the subsequent development of in utero miliary fetal tissue calcifications and fetal hydrops detected by sonogram at 15 weeks of gestation.

Case: This is a case presentation of a pregnant patient who received varicella vaccination during the same menstrual cycle that she became pregnant, and is supplemented by a literary review. The fetus developed miliary fetal tissue calcifications and fetal hydrops detected by a targeted sonogram at 15 weeks gestation.

Conclusion: Varicella vaccination during early pregnancy may be a cause of miliary fetal tissue calcifications and fetal hydrops.

Publication types

  • Case Reports

MeSH terms

  • Abortion, Therapeutic
  • Adult
  • Calcinosis / chemically induced*
  • Calcinosis / diagnostic imaging
  • Chickenpox / prevention & control*
  • Chickenpox Vaccine / administration & dosage
  • Chickenpox Vaccine / adverse effects*
  • Female
  • Fetus / pathology
  • Humans
  • Hydrops Fetalis / chemically induced*
  • Hydrops Fetalis / diagnostic imaging
  • Pregnancy
  • Pregnancy Trimester, First
  • Risk Assessment
  • Severity of Illness Index
  • Ultrasonography, Prenatal
  • Vaccination / adverse effects

Substances

  • Chickenpox Vaccine