IL-10 gene polymorphism and herpesvirus infections

M Hurme; M Haanpää; T Nurmikko; X-Y Wang; M Virta; T Pessi; S Kilpinen; J Hulkkonen; M Helminen

doi:10.1002/jmv.10320

IL-10 gene polymorphism and herpesvirus infections

J Med Virol. 2003:70 Suppl 1:S48-50. doi: 10.1002/jmv.10320.

Authors

M Hurme¹, M Haanpää, T Nurmikko, X-Y Wang, M Virta, T Pessi, S Kilpinen, J Hulkkonen, M Helminen

Affiliation

¹ Department of Microbiology and Immunology, University of Tampere Medical School and University Hospital, FIN-33014 Tampere, Finland. [email protected]

PMID: 12627487
DOI: 10.1002/jmv.10320

Abstract

Genetics has an important role in resistance to various infections and it also may modify the clinical picture of an infectious disease. Here, we briefly review our recent data demonstrating that the polymorphism of the IL-10 gene is associated with resistance to some common herpesviruses and, additionally, that this same gene is involved in the regulation of the severity of the infection and in the reactivation process.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Cytomegalovirus Infections / genetics
Cytomegalovirus Infections / immunology
Epstein-Barr Virus Infections / genetics
Epstein-Barr Virus Infections / immunology
Genotype
Haplotypes
Herpes Simplex / genetics
Herpes Simplex / immunology
Herpesviridae Infections / genetics*
Herpesviridae Infections / immunology*
Humans
Interleukin-10 / genetics*
Polymorphism, Genetic*

Substances

Interleukin-10